Week 2 NFL betting odds: Point spreads, totals and kickoff times for all 16 games

We’re on to Week 2 of the NFL season, and 16-game slate gets kicks off with Thursday night’s AFC East matchup between the Buffalo Bills and Miami Dolphins.

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Week 2 NFL betting odds: Point spreads, totals for all 16 games

Following is the complete NFL Week 1 schedule, with kickoff times, early-week consensus odds and a quick look at each of the 16 games, beginning with …

Buffalo Bills at Miami Dolphins (-2, 49 total), 8:15 p.m. ET Thursday on Amazon Prime Video

Bills have owned this rivalry of late, winning 13 of the last 15 meetings (8-6-1 against the spread), but Miami is favored for the first time since 2021.

San Francisco 49ers (-6, 45) at Minnesota Vikings, 1 p.m. Sunday

Both of these teams are 1-0 after beating the New York teams in Week 1, but the defending NFC champs are the heavy road favorite here.

Tampa Bay Buccaneers at Detroit Lions (-7, 51.5), 1 p.m. Sunday

Detroit has its second 2023 playoff rematch in as many weeks to open the 2024 season after beating the Bucs 31-23 in last January’s divisional round.

New York Giants at Washington Commanders (-2, 44), 1 p.m. Sunday

Rookie quarterback Jayden Daniels and Washington are favored, but N.Y. has gone 8-2-1 SU and 9-2 ATS in the last 11 meetings of this NFC East series.

Cleveland Browns at Jacksonville Jaguars (-3.5, 42), 1 p.m. Sunday

Two teams coming off disappointing Week 1 losses meet in the Jags’ home opener.

Las Vegas Raiders at Baltimore Ravens (-9.5, 41.5), 1 p.m. Sunday

Coming off their narrow opening loss to the Chiefs, Lamar Jackson and the Ravens return home as the largest favorites on the Week 2 slate.

New York Jets (-3.5, 41) at Tennessee Titans, 1 p.m. Sunday

Aaron Rodgers’ Jets are on the road for the second straight week, and this time they’re favored in the Titans’ home opener following Monday night’s 32-19 loss to the host 49ers.

New Orleans Saints at Dallas Cowboys (-6.5, 42.5), 1 p.m. Sunday

It’s Dallas’ home opener, and the Cowboys rank as one of the league’s best with 30-13 SU and 25-18 ATS home records since 2019.

Seattle Seahawks (-3.5, 38) at New England Patriots, 1 p.m. Sunday

The Patriots head home after springing the surprise of Week 1 in upsetting 8-point favorite Cincinnati on the road.

Indianapolis Colts (-3.5, 40.5) at Green Bay Packers, 1 p.m. Sunday

Newly-acquired backup QB Malik Willis is expected to get the start for the injured Jordan Love (knee), and Indy is now laying north of a field goal on the road as a result.

Los Angeles Chargers (-6.5, 39) at Carolina Panthers, 1 p.m. Sunday

Jim Harbaugh’s Bolts are the largest Week 2 road favorite as they head to Carolina to take on a Panthers squad which is a league-worst 2-16 SU and 4-12-2 ATS since the start of last season.

Los Angeles Rams at Arizona Cardinals (-1.5, 49.5), 4:05 p.m. Sunday

The Cards are favored in this NFC West matchup, but the Rams have dominated the series of late, going 13-2 SU and 12-2-1 ATS.

Cincinnati Bengals at Kansas City Chiefs (-6, 48), 4:25 p.m. Sunday

Joe Burrow’s Bengals are 3-2 against Patrick Mahomes’ Chiefs over the last three seasons, but K.C. has won and covered in each of the last two matchups.

Pittsburgh Steelers (-3, 36.5) at Denver Broncos, 4:25 p.m. Sunday

Broncos rookie QB Bo Nix struggled in his Week 1 debut in Seattle and now comes home for another tough test against T.J. Watt and the Steelers’ defense.

Chicago Bears at Houston Texans (-6.5 45.5), 8:20 p.m. Sunday on NBC

Top pick Caleb Williams and the Bears won in Week 1 without an offensive TD, but the challenge will be tougher this Sunday night against second-year QB C.J. Stroud and the Texans who are 7-3 at home since the start of last season.

Atlanta Falcons at Philadelphia Eagles (-6.5, 47), 8:15 p.m. Monday on ESPN

The Eagles are at home for real for a Monday night bird battle after opening with a hard-fought 34-29 victory over the packers as the “home team” in Brazil.

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